E., a greater dose of a drug is required to make precisely the same impact which was once attained at a reduced dose). CYP450 3A4 inhibitors/inducers or CYP450 2D6 inhibitors: Interactions are advanced, consult drug conversation monographs Seizures and/serotonin syndrome may come about when applied concomitantly with serotonergic agents (SSRIs, https://aliancnizdravotnictvi.com/product/tramadol/