New or worsening peripheral neuropathy might require a lowered dose or altered dose agenda (see Dosage Modification) elvitegravir/cobicistat/emtricitabine/tenofovir DF increases amounts of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nifedipine will increase the level or impact of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Cautio... https://prt062607-hydrochloride32108.blogs100.com/27220083/the-definitive-guide-to-verteporfin