The identified effect of those PTMs on ATXN2’s operate and SCA2 pathogenesis stays restricted. In other polyQ health conditions, multiple experiments instructed that proteolytic cleavage of polyQ proteins could Engage in an important purpose in pathogenesis [36, 45]. Aligned using this idea, the presence of the enriched 42 kDa fragment in https://dallasaehko.timeblog.net/64174620/the-fact-about-seltorexant-that-no-one-is-suggesting