Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators from your microenvironment and expanding the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have determined recurrent mutations in genes regulating tumor cell-microenvironment interactions, w... https://franciscol530ktc9.life3dblog.com/profile